Saturated Fat’s Dirty Secrets Revealed
October 10, 2011 by admin
Filed under News Stories
October 10, 2011
Fox News
Doctors nearly unanimously agree that eating foods loaded with saturated fats — such as butter, cream and pork in all its wondrous manifestations — can cause heart disease, obesity and diabetes. Conversely, foods with unsaturated fats, such as olives and salmon, can have the opposite effect.
Yet no one has known why, until perhaps now. As reported in the Sept. 30 issue of the journal Cell, researchers from University of California, San Diego (UCSD), found that saturated fat literally clogs cell membranes at the molecular level, causing abnormal cell signaling that ultimately throws basic metabolism out of whack. [7 Foods Your Heart Will Hate]
If the researchers are right — that is, if their work on mice proves true in humans — then they envision a new class of dietary supplements or pharmaceutical drugs to reverse the effects of a high-fat diet.
Knowledge congealed
Saturated fats tend to be solid at room temperature. They contain fatty acids that are saturated, chemically speaking, with hydrogen atoms; the carbon atoms are bonded to as many hydrogen atoms as possible. Unsaturated fats contain fatty acids with a lower ratio of carbon to hydrogen.
For over a decade researchers have known that saturated fats somehow activate enzymes associated with developing insulin resistance (a precursor to diabetes) and atherosclerosis, or clogged arteries. Unsaturated fats can block these enzymes within our cells. The enzymes, called Jun kinases, work at a subcellular level.
Building on this knowledge, a UCSD team led by Michael Karin speculated that something in cell membranes must be able to differentiate between saturated and unsaturated fats, activating or deactivating Jun kinases. In their new study, the team ultimately identified yet another enzyme, called c-Src, which resides within a cell membrane.
So, saturated fats apparently smother and push c-Src deeper into the cell membrane, to regions that are more rigid. The c-Src accumulates here and turns into an activated form that then triggers Jun kinases to start working — setting into motion the chemical reactions behind insulin resistance and circulatory disease.
Unsaturated fats, in contrast, block c-Src aggregation and thus prevent the whole cascade of troubling chemical signaling.
One pill makes you smaller
For scientists, the findings provide a new model for how cell membrane composition can trigger different signaling cascades. For non-scientists, the findings might mean that you can have your saturated fat and eat it, too.
Consider how polyunsaturated fatty acids such as EPA (also called eicosapentaenoic acid) and omega-3s are available in a pill form, more or less in their natural state. These aren’t miracle cures, but they do help some people lower their blood cholesterol (or, blood fat) levels. With a better understanding of why unsaturated fats can have protective effects, doctors might be able to identify more potent EPA-like molecules, Karin said. These molecules, delivered in a pill, could reverse the negative cycle put into effect by diabetes and other chronic disease.
If popping a pill irks you, or if you can’t wait a decade for a pill to hit the market, you can always switch to a diet that strives to reduce saturated fats. This means eating less meat and more vegetables and whole grains.
While some doctors recommend eating so-called lean cuts of meat, the very existence of lean meat necessitates the existence of fatty meat, which someone else, someone likely poorer than you, will eat. And that’s no way to feed a planet.
Click here for the full report from Fox News
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Select Sunscreens Linked To Cancer
May 24, 2010 by admin
Filed under News Stories
May 24, 2010
AOLNews.com
by Andrew Schneider
Almost half of the 500 most popular sunscreen products may actually increase the speed at which malignant cells develop and spread skin cancer because they contain vitamin A or its derivatives, according to an evaluation of those products released today.
AOL News also has learned through documents and interviews that the Food and Drug Administration has known of the potential danger for as long as a decade without alerting the public, which the FDA denies.
The study was released with Memorial Day weekend approaching. Store shelves throughout the country are already crammed with tubes, jars, bottles and spray cans of sunscreen.
The white goop, creams and ointments might prevent sunburn. But don’t count on them to keep the ultraviolet light from destroying your skin cells and causing tumors and lesions, according to researchers at Environmental Working Group.
In their annual report to consumers on sunscreen, they say that only 39 of the 500 products they examined were considered safe and effective to use.
The report cites these problems with bogus sun protection factor (SPF) numbers:
* The use of the hormone-disrupting chemical oxybenzone, which penetrates the skin and enters the bloodstream.
* Overstated claims about performance.
* The lack of needed regulations and oversight by the Food and Drug Administration.
But the most alarming disclosure in this year’s report is the finding that vitamin A and its derivatives, retinol and retinyl palmitate, may speed up the cancer that sunscreen is used to prevent.
A dangerous additive
The industry includes vitamin A in its sunscreen formulations because it is an anti-oxidant that slows skin aging.
But the EWG researchers found the initial findings of an FDA study of vitamin A’s photocarcinogenic properties, meaning the possibility that it results in cancerous tumors when used on skin exposed to sunlight.
“In that yearlong study, tumors and lesions developed up to 21 percent faster in lab animals coated in a vitamin A-laced cream than animals treated with a vitamin-free cream,” the report said.
The conclusion came from EWG’s analysis of initial findings released last fall by the FDA and the National Toxicology Program, the federal government’s principle evaluator of substances that raise public health concerns.
EWG’s conclusions were subsequently scrutinized by outside toxicologists.
Based on the strength of the findings by FDA’s own scientists, many in the public health community say they can’t believe nor understand why the agency hasn’t already notified the public of the possible danger.
“There was enough evidence 10 years ago for FDA to caution consumers against the use of vitamin A in sunscreens,” Jane Houlihan, EWG’s senior vice president for research, told AOL News.
“FDA launched this one-year study, completed their research and now 10 years later, they say nothing about it, just silence.”
On Friday, the FDA said the allegations are not true.
“We have thoroughly checked and are not aware of any studies,” an FDA spokesperson told AOL News. She said she checked with bosses throughout the agency and found no one who knew of the vitamin A sunscreen research being done by or on behalf of the agency.
But documents from the FDA and the National Toxicology Program showed that the agency had done the research.
“Retinyl palmitate was selected by (FDA’s) Center for Food Safety and Applied Nutrition for…
Click here to continue reading the full report
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Johnson & Johnson Skim Cream Ad Banned After Makeup In “After” Shots
January 20, 2010 by admin
Filed under News Stories
January 6, 2010
The Guardian
By Mark Sweney
A TV campaign for a face cream that promised to make skin look blemish-free has been banned by the advertising watchdog because the “after” shots were achieved using makeup.
The television campaign, for Johnson & Johnson, promoted the company’s Clean and Clear Spot Control Kit.
The campaign, created by ad agency DDB London, cited a trial with 30 girls using “before and after” shots and their testimonials to show the effectiveness of the anti-spot cream. “A clinical study showed 100% of people had improvement in just one day,” ran a voiceover. “After four weeks, they all had fewer spots, reduced redness and much clearer skin.”
The Advertising Standards Authority received two complaints challenging whether the images of the actresses “before and after” could be achieved using the product.
Johnson & Johnson said that the girls used were over 16 and were not models or actors. In the before shots all makeup, except eye makeup, was removed. However, for the “after” shots, Johnson & Johnson admitted that a “light powder” was applied to the girls’ skin to “remove shine from the T-zone” of the face.
The company said it did this to make sure that “the shininess did not detract from the results on the improved clarity of skin”. Johnson & Johnson said that the shots were representative of the results that can be achieved with the product.
However, the ASA said that it “noted a marked difference in the appearance of the clarity of skin between the before and after shots”.
“We considered that, in order to make the before and after comparison fair, both shots should have been taken under the same conditions (both without makeup) to ensure that any visible improvement was an accurate representation of what could be achieved with the product,” said the ASA.
